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Fat-busting pill in tests for heart profit.

Scientists in Perth, Autralia will be testing a new weight-loss pill in the hope it will not only help patients lose weight but also cut their chance of heart diseases by increasing levels of good cholesterol or HDL.

The hospital trials, as part of an international trials, could prove the weight-loss drug called Zimulti, developed by the French drugmaker Aventis, can ward off the condition known as metabolic syndrome, a particularly high risk form of obesity which entails problems controlling cholesterol, insulin and blood pressure.

Gerald Watts, Royal Perth Hospital professor of medicine, who specialises in metabolic disturbances, said the medication is expected to be sanctioned in Australia within a year and the hospital aimed to recruit 15 to 20 patients as part of the 80 being studied worldwide.

The medications that have been available until now have had toxic outcomes and some work but have no long-term safety data, so this is a new approach to the management of obesity.

The medication works by stopping chemical operations in the brain, which results in reduced appetite and also acts on the liver to help the body dissolve more fat, but side-effects can include nausea and diarrhea.

Were curious in the mechanism of how this medication works and the part it can play in fat people who have several hazard ingredients for heart disease, one of which is low HDL cholesterol, or metabolic syndrome, he said.

Professor Watts said the bottom line is to help people lose weight, which then reduces their chance of other illness such as diabetes. It means that people end up eating less and burning more fat so its a very powerful tool for targeting obesity, but beyond that its also an powerful tool for helping smoking and even alcohol mis-use, he said.

The hospital is recruiting men and women aged between 35 and 65 who are overweight or obese with a waist perimeter of more than 40inches in men and 35inches in women and have high triglycerides with low HDL cholesterol. They will be put on a diet to lose 5 per cent of their body weight and some will be selected to continue on the Zimulti trials.

In trials that have been made, the benefits that have been seen in terms of increasing HDL cholesterol could not be excused by the weight loss alone, so it clearly has a direct consequence on the good cholesterol.

Julie Carter researches health & nutrition topics. She recommends. Visit her new website Stop Smoking

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